| Title : Asperversins A and B, Two Novel Meroterpenoids with an Unusual 5\/6\/6\/6 Ring from the Marine-Derived Fungus Aspergillus versicolor - Li_2018_Mar.Drugs_16_ |
| Author(s) : Li H , Sun W , Deng M , Qi C , Chen C , Zhu H , Luo Z , Wang J , Xue Y , Zhang Y |
| Ref : Mar Drugs , 16 : , 2018 |
|
Abstract :
Asperversins A (1) and B (2), two novel meroterpenoids featuring an uncommon 5/6/6/6 ring system, along with five new analogues (3(-)7) and a known compound asperdemin (8), were obtained from the marine-derived fungus Aspergillus versicolor. Their structures and absolute configurations were confirmed by extensive spectroscopic analyses, single-crystal X-ray diffraction studies, and electronic circular dichroism (ECD) calculation. All new compounds were tested for their acetylcholinesterase enzyme (AChE) inhibitory activities and cytotoxic activities, of which compound 7 displayed moderate inhibitory activity against the AChE with an IC50 value of 13.6 μM. |
| PubMedSearch : Li_2018_Mar.Drugs_16_ |
| PubMedID: 29882867 |
Li H, Sun W, Deng M, Qi C, Chen C, Zhu H, Luo Z, Wang J, Xue Y, Zhang Y (2018)
Asperversins A and B, Two Novel Meroterpenoids with an Unusual 5\/6\/6\/6 Ring from the Marine-Derived Fungus Aspergillus versicolor
Mar Drugs
16 :
Li H, Sun W, Deng M, Qi C, Chen C, Zhu H, Luo Z, Wang J, Xue Y, Zhang Y (2018)
Mar Drugs
16 :