| Title : Genetic Manipulation of an Aminotransferase Family Gene dtlA Activates Youssoufenes in Marine-Derived Streptomyces youssoufiensis - Li_2020_Org.Lett_22_729 |
| Author(s) : Li H , Liu J , Deng Z , Li T , Liu Z , Che Q , Li W |
| Ref : Org Lett , 22 :729 , 2020 |
|
Abstract :
Disruption of an aminotransferase family gene dtlA activated the production of a novel dimeric benzoic polyene acids (BPAs), named youssoufene A1 (1), along with four new (2-5, youssoufenes B1-B4) and a known (6) monomeric BPA in the marine-derived Streptomyces youssoufiensis OUC6819. The structures of 1-5 were elucidated by extensive spectroscopic and computational approaches. Youssoufene A1 (1) exhibited notably increased growth inhibition (MIC = 12.5 microg/mL) against multidrug resistant Enterococcus faecalis compared to monomeric structures (2-6). |
| PubMedSearch : Li_2020_Org.Lett_22_729 |
| PubMedID: 31891272 |
| Gene_locus related to this paper: 9actn-YsfF |
| Gene_locus | 9actn-YsfF |
Li H, Liu J, Deng Z, Li T, Liu Z, Che Q, Li W (2020)
Genetic Manipulation of an Aminotransferase Family Gene dtlA Activates Youssoufenes in Marine-Derived Streptomyces youssoufiensis
Org Lett
22 :729
Li H, Liu J, Deng Z, Li T, Liu Z, Che Q, Li W (2020)
Org Lett
22 :729