Title : Neolignans in Magnolia officinalis as natural anti-Alzheimer's disease agents: A systematic review - Li_2024_Ageing.Res.Rev_99_102398 |
Author(s) : Li N , Liang Y , Zhang L , Xu C , Wang L |
Ref : Ageing Res Rev , 99 :102398 , 2024 |
Abstract :
BACKGROUND: Magnolia officinalis, a traditional herbal medicine widely used in clinical practice, exerts antibacterial, anti-tumor, anti-inflammatory, antioxidant, and anti-aging activities. Neolignans are the main active ingredients of M. officinalis and exert a wide range of pharmacological effects, including anti-Alzheimer's disease (AD) activity. OBJECTIVE: To summarize the published data on the therapeutic effect and mechanism of neolignans on AD in vivo and in vitro. METHODS: PubMed, Web of Science, Google Scholar, and Scopus were systematically reviewed (up to March 1, 2024) for pre-clinical studies. RESULTS: M. officinalis-derived neolignans (honokiol, magnolol, 4-O-methylhonokiol, and obovatol) alleviated behavioral abnormalities, including learning and cognitive impairments, in AD animal models. Mechanistically, neolignans inhibited Abeta generation or aggregation, neuroinflammation, and acetylcholinesterase activity; promoted microglial phagocytosis and anti-oxidative stress; alleviated mitochondrial dysfunction and energy metabolism, as well as anti-cholinergic deficiency; and regulated intestinal flora. Furthermore, neolignans may achieve neuroprotection by regulating different molecular pathways, including the NF-kappaB, ERK, AMPK/mTOR/ULK1, and cAMP/PKA/CREB pathways. CONCLUSIONS: Neolignans exert anti-AD effects through multiple mechanisms and pathways. However, the exact targets, pharmacokinetics, safety, and clinical efficacy in patients with AD need further investigation in multi-center clinical case-control studies. |
PubMedSearch : Li_2024_Ageing.Res.Rev_99_102398 |
PubMedID: 38955265 |
Li N, Liang Y, Zhang L, Xu C, Wang L (2024)
Neolignans in Magnolia officinalis as natural anti-Alzheimer's disease agents: A systematic review
Ageing Res Rev
99 :102398
Li N, Liang Y, Zhang L, Xu C, Wang L (2024)
Ageing Res Rev
99 :102398