| Title : Multioxidized polyketides from an endophytic Penicillium sp. YUD17006 associated with Gastrodia elata - Li_2024_Chin.J.Nat.Med_22_1057 |
| Author(s) : Li H , Yang R , Xie F , Xie T , Tang L , Zhou H , Ding Z |
| Ref : Chin J Nat Med , 22 :1057 , 2024 |
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Abstract :
Three novel, highly oxygenated polyketides, multioketides A-C (1-3), and three previously described multioxidized aromatic polyketides (4-6), were isolated from an endophytic Penicillium sp. YUD17006 associated with Gastrodia elata. Their chemical structures were elucidated using extensive spectroscopic data, electronic circular dichroism calculations, and single X-ray diffraction analysis. All metabolites were characterized by a typical alpha,beta-unsaturated ketone fragment and exhibited a high degree of oxidation. Multioketides A and B were identified as a pair of epimers featuring a rare dihydroisobenzofuranone core. Multioketide C possessed a novel 5/6/6/6 heterotetracyclic chemical architecture with unusual 1,4-dioxin functionalities. Plausible biosynthetic pathways for 1-6 were proposed. Additionally, compound 3 demonstrated weak inhibitory activities against both acetylcholinesterase and protein tyrosine phosphatase 1B. |
| PubMedSearch : Li_2024_Chin.J.Nat.Med_22_1057 |
| PubMedID: 39510638 |
Li H, Yang R, Xie F, Xie T, Tang L, Zhou H, Ding Z (2024)
Multioxidized polyketides from an endophytic Penicillium sp. YUD17006 associated with Gastrodia elata
Chin J Nat Med
22 :1057
Li H, Yang R, Xie F, Xie T, Tang L, Zhou H, Ding Z (2024)
Chin J Nat Med
22 :1057