| Title : The essential oil of Eucalyptus tereticornis, and its constituents alpha- and beta-pinene, potentiate acetylcholine-induced contractions in isolated rat trachea - Lima_2010_Fitoterapia_81_649 |
| Author(s) : Lima FJ , Brito TS , Freire WB , Costa RC , Linhares MI , Sousa FC , Lahlou S , Leal-Cardoso JH , Santos AA , Magalhaes PJ |
| Ref : Fitoterapia , 81 :649 , 2010 |
| Abstract : The effects of the essential oil of Eucalyptus tereticornis (EOET), especially the effects of its constituents alpha- and beta-pinene, were studied on rat trachea in vitro. In tracheal rings, EOET, alpha- or beta-pinene potentiated the contractions induced by acetylcholine (ACh). Contractions induced by K(+) (60mM) were also potentiated by alpha- and beta-pinene, but were reduced by EOET. Our findings show that EOET has myorelaxant effects on rat airways, but potentiates ACh-induced contractions. Monoterpenes alpha- and beta-pinene are involved in its potentiating actions, but are not responsible for its myorelaxant effects. A putative inhibition of the acetylcholinesterase enzyme is involved. |
| ESTHER : Lima_2010_Fitoterapia_81_649 |
| PubMedSearch : Lima_2010_Fitoterapia_81_649 |
| PubMedID: 20302920 |
Lima FJ, Brito TS, Freire WB, Costa RC, Linhares MI, Sousa FC, Lahlou S, Leal-Cardoso JH, Santos AA, Magalhaes PJ (2010)
The essential oil of Eucalyptus tereticornis, and its constituents alpha- and beta-pinene, potentiate acetylcholine-induced contractions in isolated rat trachea
Fitoterapia
81 :649
Lima FJ, Brito TS, Freire WB, Costa RC, Linhares MI, Sousa FC, Lahlou S, Leal-Cardoso JH, Santos AA, Magalhaes PJ (2010)
Fitoterapia
81 :649