| Title : Predicted acetylcholine layer around embryonic motoneurones - Limozin_1997_Neuroreport_8_2957 |
| Author(s) : Limozin L , Pelce P , Savtchenko L , Chamoin MC , Ternaux JP |
| Ref : Neuroreport , 8 :2957 , 1997 |
| Abstract : The secretion of acetylcholine (ACh) from cultures of dissociated rat purified embryonic motoneurones into the medium was measured at different times using a chemiluminescent assay. From these results it is proposed that a motoneurone is able to generate an extracellular ACh layer surrounding its membrane. This layer is expected to modulate the ACh concentration at the membrane in a range where ACh receptors can be sensitive, and thus to affect the response of the motoneurone. The influences of both membrane-bound and soluble-secreted acetylcholinesterase (AChE) were simulated and a local ACh membrane efflux was deduced. Since ACh usually exerts an inhibitory effect on neurite outgrowth, a possible autocrine influence of the ACh layer in motoneurone morphogenesis is discussed. |
| ESTHER : Limozin_1997_Neuroreport_8_2957 |
| PubMedSearch : Limozin_1997_Neuroreport_8_2957 |
| PubMedID: 9376538 |
Limozin L, Pelce P, Savtchenko L, Chamoin MC, Ternaux JP (1997)
Predicted acetylcholine layer around embryonic motoneurones
Neuroreport
8 :2957
Limozin L, Pelce P, Savtchenko L, Chamoin MC, Ternaux JP (1997)
Neuroreport
8 :2957