| Title : Draft genome sequences of two super-extensively drug-resistant isolates of Mycobacterium tuberculosis from China - Lin_2013_FEMS.Microbiol.Lett_347_93 |
| Author(s) : Lin N , Liu Z , Zhou J , Wang S , Fleming J |
| Ref : FEMS Microbiology Letters , 347 :93 , 2013 |
|
Abstract :
The prevalence of drug-resistance in Mycobacterium tuberculosis is already having a negative impact on the control of tuberculosis. We report the draft genome sequences of two super-extensively drug-resistant M. tuberculosis isolates from China, FJ05194 (lineage 2) and GuangZ0019 (lineage 4), and compare them with the H37Rv reference strain to identify possible sources of genetic variation associated with their extensive drug resistance. Our results suggest that their extensive drug resistance probably results from the stepwise accumulation of resistances to individual drugs. |
| PubMedSearch : Lin_2013_FEMS.Microbiol.Lett_347_93 |
| PubMedID: 23965132 |
| Gene_locus related to this paper: mycmm-b2ht49 , myctu-cut3 , myctu-Rv1069c , myctu-RV1215C , myctu-Rv2045c |
| Gene_locus | mycmm-b2ht49 myctu-cut3 myctu-Rv1069c myctu-RV1215C myctu-Rv2045c |
| Gene_locus_frgt | myctu-Rv1104 |
Lin N, Liu Z, Zhou J, Wang S, Fleming J (2013)
Draft genome sequences of two super-extensively drug-resistant isolates of Mycobacterium tuberculosis from China
FEMS Microbiology Letters
347 :93
Lin N, Liu Z, Zhou J, Wang S, Fleming J (2013)
FEMS Microbiology Letters
347 :93