| Title : Rapid degradation of oseltamivir phosphate in clinical samples by plasma esterases - Lindegardh_2006_Antimicrob.Agents.Chemother_50_3197 |
| Author(s) : Lindegardh N , Davies GR , Tran TH , Farrar J , Singhasivanon P , Day NP , White NJ |
| Ref : Antimicrobial Agents & Chemotherapy , 50 :3197 , 2006 |
|
Abstract :
The anti-influenza drug oseltamivir is an ester prodrug activated by hepatic carboxylesterases. Plasma esterases also convert up to 31.8% of the parent compound to the active metabolite after 4 h ex vivo, with wide interindividual variation. This source of error is removed by adding the esterase inhibitor dichlorvos to blood collection tubes. |
| PubMedSearch : Lindegardh_2006_Antimicrob.Agents.Chemother_50_3197 |
| PubMedID: 16940130 |
| Substrate | Oseltamivir |
Lindegardh N, Davies GR, Tran TH, Farrar J, Singhasivanon P, Day NP, White NJ (2006)
Rapid degradation of oseltamivir phosphate in clinical samples by plasma esterases
Antimicrobial Agents & Chemotherapy
50 :3197
Lindegardh N, Davies GR, Tran TH, Farrar J, Singhasivanon P, Day NP, White NJ (2006)
Antimicrobial Agents & Chemotherapy
50 :3197