Liu_2007_Drug.Metab.Dispos_35_521

Reference

Title : Characterization of two cyclic metabolites of sitagliptin - Liu_2007_Drug.Metab.Dispos_35_521
Author(s) : Liu DQ , Arison BH , Stearns RA , Kim D , Vincent SH
Ref : Drug Metabolism & Disposition: The Biological Fate of Chemicals , 35 :521 , 2007
Abstract :

Two novel metabolites of the dipeptidyl peptidase inhibitor sitagliptin (MK-0431, (2R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)- yl]-1-(2,4,5-trifluorophenyl)-butan-2-amine), were identified after purification from dog urine. The metabolites (referred to as M2 and M5) were characterized by hydrogen/deuterium exchange tandem mass spectrometry and NMR spectroscopy nuclear Overhauser effect experiments as the cis and trans stereoisomers formed by cyclization of the primary amino group with the alpha carbon of the piperazine ring, following oxidative desaturation.

PubMedSearch : Liu_2007_Drug.Metab.Dispos_35_521
PubMedID: 17220240

Related information

Inhibitor Sitagliptin

Citations formats

Liu DQ, Arison BH, Stearns RA, Kim D, Vincent SH (2007)
Characterization of two cyclic metabolites of sitagliptin
Drug Metabolism & Disposition: The Biological Fate of Chemicals 35 :521

Liu DQ, Arison BH, Stearns RA, Kim D, Vincent SH (2007)
Drug Metabolism & Disposition: The Biological Fate of Chemicals 35 :521