| Title : Bioactive Polyprenylated Acylphloroglucinol Derivatives from Hypericum cohaerens - Liu_2013_J.Nat.Prod_76_1612 |
| Author(s) : Liu X , Yang XW , Chen CQ , Wu CY , Zhang JJ , Ma JZ , Wang H , Yang LX , Xu G |
| Ref : Journal of Natural Products , 76 :1612 , 2013 |
|
Abstract :
Nine new polyprenylated acylphloroglucinol derivatives, hypercohins B-J (1-9), and nine known analogues were isolated from the aerial parts of Hypericum cohaerens. The structures of 1-9 were elucidated based on spectroscopic analysis, and the absolute configuration of 1 was confirmed by X-ray crystallographic analysis. The inhibitory activities of these isolates on acetylcholinesterase and five human tumor cell lines were tested, and hypercohins B-D (1-3) exhibited moderate inhibitory activity (IC50 5.8-17.9 muM) against the tested tumor cell lines. |
| PubMedSearch : Liu_2013_J.Nat.Prod_76_1612 |
| PubMedID: 23957453 |
Liu X, Yang XW, Chen CQ, Wu CY, Zhang JJ, Ma JZ, Wang H, Yang LX, Xu G (2013)
Bioactive Polyprenylated Acylphloroglucinol Derivatives from Hypericum cohaerens
Journal of Natural Products
76 :1612
Liu X, Yang XW, Chen CQ, Wu CY, Zhang JJ, Ma JZ, Wang H, Yang LX, Xu G (2013)
Journal of Natural Products
76 :1612