| Title : Norfriedelins A-C with acetylcholinesterase inhibitory activity from acerola tree (Malpighia emarginata) - Liu_2013_Org.Lett_15_1580 |
| Author(s) : Liu JQ , Peng XR , Li XY , Li TZ , Zhang WM , Shi L , Han J , Qiu MH |
| Ref : Org Lett , 15 :1580 , 2013 |
|
Abstract :
Three novel norfriedelanes, A-C (1-3), were isolated from the branches and roots of Malpighia emarginata . Their structures and absolute configurations were determined by 1D and 2D NMR techniques and X-ray crystallographic analysis. Norfriedelin A (possessing an alpha-oxo-beta-lactone group) and norfriedelin B (with a keto-lactone group) showed acetylcholinesterase inhibitory effects with the IC50 values of 10.3 and 28.7 muM, respectively. |
| PubMedSearch : Liu_2013_Org.Lett_15_1580 |
| PubMedID: 23484960 |
Liu JQ, Peng XR, Li XY, Li TZ, Zhang WM, Shi L, Han J, Qiu MH (2013)
Norfriedelins A-C with acetylcholinesterase inhibitory activity from acerola tree (Malpighia emarginata)
Org Lett
15 :1580
Liu JQ, Peng XR, Li XY, Li TZ, Zhang WM, Shi L, Han J, Qiu MH (2013)
Org Lett
15 :1580