| Title : Colocynthenins A-D, Ring-A seco-Cucurbitane Triterpenoids from the Fruits of Citrullus colocynthis - Liu_2018_J.Nat.Prod_81_2115 |
| Author(s) : Liu Y , Chen G , Chen X , Chen SX , Gan LS , Yuan T |
| Ref : Journal of Natural Products , 81 :2115 , 2018 |
|
Abstract :
Four ring-A seco-cucurbitane triterpenoids, colocynthenins A-D (1-4), together with seven known cucurbitane triterpenoids (5-11), were isolated from the fruits of Citrullus colocynthis. Their structures and absolute configurations were elucidated based on spectroscopic analysis and quantum chemical ECD calculations. Compound 1 possesses an unprecedented 2,11-lactone moiety, while compound 2 is the first reported cucurbitane triterpenoid with an unusual cyano group. Compounds 1 and 3 showed acetylcholinesterase inhibitory activities in a standard in vitro assay, with IC50 values of 2.6 and 3.1 muM, respectively. |
| PubMedSearch : Liu_2018_J.Nat.Prod_81_2115 |
| PubMedID: 30183289 |
Liu Y, Chen G, Chen X, Chen SX, Gan LS, Yuan T (2018)
Colocynthenins A-D, Ring-A seco-Cucurbitane Triterpenoids from the Fruits of Citrullus colocynthis
Journal of Natural Products
81 :2115
Liu Y, Chen G, Chen X, Chen SX, Gan LS, Yuan T (2018)
Journal of Natural Products
81 :2115