Livolsi_2010_PLoS.One_5_e9464

Reference

Title : Cardiac muscarinic receptor overexpression in sudden infant death syndrome - Livolsi_2010_PLoS.One_5_e9464
Author(s) : Livolsi A , Niederhoffer N , Dali-Youcef N , Rambaud C , Olexa C , Mokni W , Gies JP , Bousquet P
Ref : PLoS ONE , 5 :e9464 , 2010
Abstract :

BACKGROUND: Sudden infant death syndrome (SIDS) remains the leading cause of death among infants less than 1 year of age. Disturbed expression of some neurotransmitters and their receptors has been shown in the central nervous system of SIDS victims but no biological abnormality of the peripheral vago-cardiac system has been demonstrated to date. The present study aimed to seek vago-cardiac abnormalities in SIDS victims. The cardiac level of expression of muscarinic receptors, as well as acetylcholinesterase enzyme activity were investigated. METHODOLOGY/PRINCIPAL FINDINGS: Left ventricular samples and blood samples were obtained from autopsies of SIDS and children deceased from non cardiac causes. Binding experiments performed with [(3)H]NMS, a selective muscarinic ligand, in cardiac membrane preparations showed that the density of cardiac muscarinic receptors was increased as shown by a more than doubled B(max) value in SIDS (n = 9 SIDS versus 8 controls). On average, the erythrocyte acetylcholinesterase enzyme activity was also significantly increased (n = 9 SIDS versus 11 controls). CONCLUSIONS: In the present study, it has been shown for the first time that cardiac muscarinic receptor overexpression is associated with SIDS. The increase of acetylcholinesterase enzyme activity appears as a possible regulatory mechanism.

PubMedSearch : Livolsi_2010_PLoS.One_5_e9464
PubMedID: 20209124

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Citations formats

Livolsi A, Niederhoffer N, Dali-Youcef N, Rambaud C, Olexa C, Mokni W, Gies JP, Bousquet P (2010)
Cardiac muscarinic receptor overexpression in sudden infant death syndrome
PLoS ONE 5 :e9464

Livolsi A, Niederhoffer N, Dali-Youcef N, Rambaud C, Olexa C, Mokni W, Gies JP, Bousquet P (2010)
PLoS ONE 5 :e9464