| Title : Presynaptic calcium currents and their relation to synaptic transmission: voltage clamp study in squid giant synapse and theoretical model for the calcium gate - Llinas_1976_Proc.Natl.Acad.Sci.U.S.A_73_2918 |
| Author(s) : Llinas R , Steinberg IZ , Walton K |
| Ref : Proc Natl Acad Sci U S A , 73 :2918 , 1976 |
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Abstract :
A voltage clamp study of the presynaptic terminal in squid stellate ganglion has given quantitative results relating inward Ca2+ current to presynaptic membrane potential and postsynaptic response to inward Ca2+ current. The results indicate an S-shaped curve for the relationship between presynaptic potential and Ca2+ current and a linear relationship between Ca2+ current and postsynaptic potential. A similar S-shaped curve was found for the time-dependent properties of the Ca2+ conductance. Based on these results a mathematical model was developed which accounts for the experimental results in this and previously published papers by other authors. The model suggests that five subunits are involved in the Ca2+ gate and that the subunits change noncooperatively from an inactive to an active form upon membrane depolarization. |
| PubMedSearch : Llinas_1976_Proc.Natl.Acad.Sci.U.S.A_73_2918 |
| PubMedID: 183215 |
Llinas R, Steinberg IZ, Walton K (1976)
Presynaptic calcium currents and their relation to synaptic transmission: voltage clamp study in squid giant synapse and theoretical model for the calcium gate
Proc Natl Acad Sci U S A
73 :2918
Llinas R, Steinberg IZ, Walton K (1976)
Proc Natl Acad Sci U S A
73 :2918