Title : Neurotrophic factors increase neuregulin expression in embryonic ventral spinal cord neurons - Loeb_1997_J.Neurosci_17_1416 |
Author(s) : Loeb JA , Fischbach GD |
Ref : Journal of Neuroscience , 17 :1416 , 1997 |
Abstract :
Neuregulins (NRGs) are expressed in spinal cord motor neurons and accumulate at the neuromuscular junction where they may increase the synthesis of postsynaptic acetylcholine receptors and voltage-gated sodium channels. We demonstrate here that NRG expression is selectively increased in rat ventral spinal cord neurons at approximately the time that nerve-muscle synapses first form. A rapid increase in NRG mRNA and protein expression was induced in vitro in cultured rat spinal motor neurons by brain-derived neurotrophic factor, neurotrophin-3, neurotrophin-4, or glial-cell-line-derived neurotrophic factor. Agrin expression was not affected by these factors over the same time course. Brain-derived neurotrophic factor, but not neurotrophin-3, selectively regulated immunoglobulin domain-containing splice variants of NRG, which are likely to be important for binding to the synaptic basal lamina. Regulation of NRG expression in motor neurons by muscle-derived neurotrophic factors may represent one portion of a reciprocal, regulatory loop that promotes neuromuscular synapse development. |
PubMedSearch : Loeb_1997_J.Neurosci_17_1416 |
PubMedID: 9006983 |
Loeb JA, Fischbach GD (1997)
Neurotrophic factors increase neuregulin expression in embryonic ventral spinal cord neurons
Journal of Neuroscience
17 :1416
Loeb JA, Fischbach GD (1997)
Journal of Neuroscience
17 :1416