| Title : Effects of long-term administration of lithium and hydrochlorothiazide in rats - Loghin_1999_Met.Based.Drugs_6_87 |
| Author(s) : Loghin F , Olinic A , Popa DS , Socaciu C , Leucuta SE |
| Ref : Met Based Drugs , 6 :87 , 1999 |
| Abstract : The biochemical and histological changes following 60 days administration of daily doses equivalent to 1/20 LD(50) of lithium lactate and hydrochlorothiazide, as such and in association, were studied in male Wistar rats. No mortality or overt signs of toxicity were observed during the experiment and the serum activities of transaminases, alkaline phosphatase and cholinesterase were not significantly modified compared to controls. The histopathological examination of all the investigated organs: kidney, liver, brain and spleen, revealed significant lesions which were time-dependant and more pronounced in the association group. Although the changes were mostly inflammatory and conqestive, it was proved that the concomitant administration of lithium and hydrochlorothiazid is potentially dangerous, increasing lithium's nephrotoxicity and the thiazide diuretic's hepatotoxicity. |
| ESTHER : Loghin_1999_Met.Based.Drugs_6_87 |
| PubMedSearch : Loghin_1999_Met.Based.Drugs_6_87 |
| PubMedID: 18475886 |
Loghin F, Olinic A, Popa DS, Socaciu C, Leucuta SE (1999)
Effects of long-term administration of lithium and hydrochlorothiazide in rats
Met Based Drugs
6 :87
Loghin F, Olinic A, Popa DS, Socaciu C, Leucuta SE (1999)
Met Based Drugs
6 :87