Lotfipour_2011_Curr.Med.Imaging.Rev_7_107

Reference

Title : Quantitative Molecular Imaging of Neuronal Nicotinic Acetylcholine Receptors in the Human Brain with A-85380 Radiotracers - Lotfipour_2011_Curr.Med.Imaging.Rev_7_107
Author(s) : Lotfipour S , Mandelkern M , Brody AL
Ref : Curr Med Imaging Rev , 7 :107 , 2011
Abstract :

Neuronal nicotinic acetylcholine receptors (nAChRs) have been implicated in a spectrum of cognitive functions as well as psychiatric and neurodegenerative disorders, including tobacco addiction and Alzheimer's Disease. The examination of neuronal nAChRs in living humans is a relatively new field. Researchers have developed brain-imaging radiotracers for nAChRs, with radiolabeled A-85380 compounds having the most widespread use. We provide a brief background on nAChRs, followed by a discussion of the development and application of A-85380 radiotracers in human imaging studies. We describe potential future studies using nicotinic receptor radioligands for the study of tobacco addiction, including the mechanism of action of the smoking-cessation therapy varenicline. Throughout this review, we focus on the significant potential that resides in the identification and quantification of nAChRs in the living human brain.

PubMedSearch : Lotfipour_2011_Curr.Med.Imaging.Rev_7_107
PubMedID: 22773924

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Citations formats

Lotfipour S, Mandelkern M, Brody AL (2011)
Quantitative Molecular Imaging of Neuronal Nicotinic Acetylcholine Receptors in the Human Brain with A-85380 Radiotracers
Curr Med Imaging Rev 7 :107

Lotfipour S, Mandelkern M, Brody AL (2011)
Curr Med Imaging Rev 7 :107