| Title : IL-4 in vitro production is upregulated in Alzheimer's disease patients treated with acetylcholinesterase inhibitors - Lugaresi_2004_Exp.Gerontol_39_653 |
| Author(s) : Lugaresi A , Di Iorio A , Iarlori C , Reale M , De Luca G , Sparvieri E , Michetti A , Conti P , Gambi D , Abate G , Paganelli R |
| Ref : Experimental Gerontology , 39 :653 , 2004 |
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Abstract :
Cytokines appear to be involved in the pathogenesis of Alzheimer's Disease (AD). Their modulation by treatment has been investigated only in a few studies. The aim of our study was to evaluate the effect of acetylcholinesterase inhibitors (AChEI) on Interleukin-4 (IL-4) production in AD patients. IL-4 levels were measured by ELISA on peripheral blood mononuclear cell cultures in the presence or absence of Concanavalin A or Phytohaemagglutinin. Linear regression analysis shows that patients who have been treated, have higher levels of IL-4 independently from age, gender and comorbidity. The increased production of IL-4 in AChEI treated patients might represent an additional mechanism through which AChEI act on AD progression. |
| PubMedSearch : Lugaresi_2004_Exp.Gerontol_39_653 |
| PubMedID: 15050302 |
Lugaresi A, Di Iorio A, Iarlori C, Reale M, De Luca G, Sparvieri E, Michetti A, Conti P, Gambi D, Abate G, Paganelli R (2004)
IL-4 in vitro production is upregulated in Alzheimer's disease patients treated with acetylcholinesterase inhibitors
Experimental Gerontology
39 :653
Lugaresi A, Di Iorio A, Iarlori C, Reale M, De Luca G, Sparvieri E, Michetti A, Conti P, Gambi D, Abate G, Paganelli R (2004)
Experimental Gerontology
39 :653