| Title : Involvement of ionotropic glutamate receptors in the appearance of arecoline tremor in mice - Lukomskaya_2008_Neurosci.Behav.Physiol_38_421 |
| Author(s) : Lukomskaya NY , Lavrent'eva VV , Starshinova LA , Zhabko EP , Gmiro VE , Magazanik LG |
| Ref : Neurosci Behav Physiol , 38 :421 , 2008 |
| Abstract : Administration of the muscarinic cholinoreceptor agonist arecoline (6 mg/kg, s.c.) to mice induced long-lasting tremor. The ability of non-competitive antagonists of ionotropic glutamate receptors to suppress the onset of tremor was studied. These antagonists, i.e., adamantane and phenylcyclohexyl derivatives, selectively blocked NMDA-type receptor channels (monocations) or both NMDA-and AMPA-type channels (dications). Both types of blocker weakened arecoline tremor, though the dose-response relationships were different for mono-and dications. The effects of dications appeared only at low blocker doses (0.0001-0.01 micromol/kg) but gradually disappeared on dose elevation. These data lead to the conclusion that the mechanism of pathogenesis of arecoline tremor predominantly involves NMDA-type receptors. Moderate blockade of AMPA-type receptors could potentiate the preventive effect of mixed-action antagonists (anti-NMDA+anti-AMPA), though predominance of blocking action against AMPA-type receptors prevented this effect. |
| ESTHER : Lukomskaya_2008_Neurosci.Behav.Physiol_38_421 |
| PubMedSearch : Lukomskaya_2008_Neurosci.Behav.Physiol_38_421 |
| PubMedID: 18401736 |
Lukomskaya NY, Lavrent'eva VV, Starshinova LA, Zhabko EP, Gmiro VE, Magazanik LG (2008)
Involvement of ionotropic glutamate receptors in the appearance of arecoline tremor in mice
Neurosci Behav Physiol
38 :421
Lukomskaya NY, Lavrent'eva VV, Starshinova LA, Zhabko EP, Gmiro VE, Magazanik LG (2008)
Neurosci Behav Physiol
38 :421