Lukomskaya_2008_Neurosci.Behav.Physiol_38_421

Reference

Title : Involvement of ionotropic glutamate receptors in the appearance of arecoline tremor in mice - Lukomskaya_2008_Neurosci.Behav.Physiol_38_421
Author(s) : Lukomskaya NY , Lavrent'eva VV , Starshinova LA , Zhabko EP , Gmiro VE , Magazanik LG
Ref : Neurosci Behav Physiol , 38 :421 , 2008
Abstract :

Administration of the muscarinic cholinoreceptor agonist arecoline (6 mg/kg, s.c.) to mice induced long-lasting tremor. The ability of non-competitive antagonists of ionotropic glutamate receptors to suppress the onset of tremor was studied. These antagonists, i.e., adamantane and phenylcyclohexyl derivatives, selectively blocked NMDA-type receptor channels (monocations) or both NMDA-and AMPA-type channels (dications). Both types of blocker weakened arecoline tremor, though the dose-response relationships were different for mono-and dications. The effects of dications appeared only at low blocker doses (0.0001-0.01 micromol/kg) but gradually disappeared on dose elevation. These data lead to the conclusion that the mechanism of pathogenesis of arecoline tremor predominantly involves NMDA-type receptors. Moderate blockade of AMPA-type receptors could potentiate the preventive effect of mixed-action antagonists (anti-NMDA+anti-AMPA), though predominance of blocking action against AMPA-type receptors prevented this effect.

PubMedSearch : Lukomskaya_2008_Neurosci.Behav.Physiol_38_421
PubMedID: 18401736

Related information

Citations formats

Lukomskaya NY, Lavrent'eva VV, Starshinova LA, Zhabko EP, Gmiro VE, Magazanik LG (2008)
Involvement of ionotropic glutamate receptors in the appearance of arecoline tremor in mice
Neurosci Behav Physiol 38 :421

Lukomskaya NY, Lavrent'eva VV, Starshinova LA, Zhabko EP, Gmiro VE, Magazanik LG (2008)
Neurosci Behav Physiol 38 :421