| Title : Differential inhibition of the release of endogenous and newly synthesized acetylcholine from Torpedo synaptosomes by presynaptic muscarinic receptors - Luz_1983_FEBS.Lett_164_9 |
| Author(s) : Luz S , Pinchasi I , Michaelson DM |
| Ref : FEBS Letters , 164 :9 , 1983 |
|
Abstract :
Activation of Torpedo presynaptic muscarinic acetylcholine (ACh) receptors with the agonist oxotremorine (20 microM) results in the inhibition of Ca2+-dependent release of endogenous ACh from Torpedo synaptosomes. This effect is reversed by the muscarinic antagonist atropine (1 microM) which, by itself, has no effect. In contrast, under the same conditions the amount of newly synthesized radiolabeled [3H]ACh released is not affected by muscarinic ligands. These findings suggest that presynaptic muscarinic inhibition in the Torpedo is due to interference with the mobilization of ACh from a storage pool. |
| PubMedSearch : Luz_1983_FEBS.Lett_164_9 |
| PubMedID: 6653788 |
Luz S, Pinchasi I, Michaelson DM (1983)
Differential inhibition of the release of endogenous and newly synthesized acetylcholine from Torpedo synaptosomes by presynaptic muscarinic receptors
FEBS Letters
164 :9
Luz S, Pinchasi I, Michaelson DM (1983)
FEBS Letters
164 :9