| Title : Synthesis, crystal structure, and biological evaluation of optically active 2-amino-4-aryl-7,7-dimethyl-5-oxo-5,6,7,8-tetrahydro-4H-chromen-3-carbonitriles: Antiepileptic, antidiabetic, and anticholinergics potentials - Maharramov_2019_Arch.Pharm.(Weinheim)__e1800317 |
| Author(s) : Maharramov A , Kaya R , Taslimi P , Kurbanova M , Sadigova A , Farzaliyev V , Sujayev A , Gulcin I |
| Ref : Arch Pharm (Weinheim) , :e1800317 , 2019 |
|
Abstract :
In the presence of chiral organic catalysts, the optically active 4H-chromine was synthesized from the multicomponent condensation of 5,5-dimethylcyclohexane-1,3-dione with malononitrile and methylene-active compound, and the specific angle of rotation of the compounds was determined in the AUTOPOL-III polarimeter and their structures were confirmed by the X-ray spectroscopic analysis method. These optically active 2-amino-4-aryl-7,7-dimethyl-5-oxo-5,6,7,8-tetrahydro-4H-chromen-3-carbonitriles were effective inhibitors of alpha-glycosidase, the cytosolic carbonic anhydrase I and II isoforms (hCA I and II), and acetylcholinesterase (AChE) enzymes with Ki values in the range of 21.33 +/- 1.11 to 40.24 +/- 10.78 muM for hCA I, 28.91 +/- 6.51 to 59.97 +/- 15.62 muM for hCA II, 18.16 +/- 3.18 to 66.57 +/- 1.36 muM for alpha-glycosidase, and 8.68 +/- 0.93 to 102.61 +/- 24.96 muM for AChE. |
| PubMedSearch : Maharramov_2019_Arch.Pharm.(Weinheim)__e1800317 |
| PubMedID: 30600532 |
Maharramov A, Kaya R, Taslimi P, Kurbanova M, Sadigova A, Farzaliyev V, Sujayev A, Gulcin I (2019)
Synthesis, crystal structure, and biological evaluation of optically active 2-amino-4-aryl-7,7-dimethyl-5-oxo-5,6,7,8-tetrahydro-4H-chromen-3-carbonitriles: Antiepileptic, antidiabetic, and anticholinergics potentials
Arch Pharm (Weinheim)
:e1800317
Maharramov A, Kaya R, Taslimi P, Kurbanova M, Sadigova A, Farzaliyev V, Sujayev A, Gulcin I (2019)
Arch Pharm (Weinheim)
:e1800317