| Title : Immunosuppression of rat myasthenia gravis by oral administration of a syngeneic acetylcholine receptor fragment - Maiti_2004_J.Neuroimmunol_152_112 |
| Author(s) : Maiti PK , Feferman T , Im SH , Souroujon MC , Fuchs S |
| Ref : Journal of Neuroimmunology , 152 :112 , 2004 |
|
Abstract :
A syngeneic rat recombinant fragment of the extracellular domain of the acetylcholine receptor (AChR) alpha-subunit (Ralpha1-205), administered orally, suppresses ongoing experimental autoimmune myasthenia gravis (EAMG) in rats. The underlying mechanism is a shift from Th1 to Th2 regulation as evidenced by downregulated mRNA expression levels of IFN-gamma and TNF-alpha, upregulated IL-10, changes in anti-AChR IgG isotypes and diminished Th1 signaling via CD28/CTLA-4:B7. Unlike the xenogeneic fragment, the syngeneic Ralpha1-205 does not induce elevation in TGF-beta and elicitation of autoregulatory cells. The ability to suppress EAMG by a non-immunogenic syngeneic fragment of AChR is encouraging and may in the future be applied for the treatment of myasthenia gravis in humans. |
| PubMedSearch : Maiti_2004_J.Neuroimmunol_152_112 |
| PubMedID: 15223243 |
Maiti PK, Feferman T, Im SH, Souroujon MC, Fuchs S (2004)
Immunosuppression of rat myasthenia gravis by oral administration of a syngeneic acetylcholine receptor fragment
Journal of Neuroimmunology
152 :112
Maiti PK, Feferman T, Im SH, Souroujon MC, Fuchs S (2004)
Journal of Neuroimmunology
152 :112