| Title : Diuretic and natriuretic effect of ebelactone B in anesthetized rats by inhibition of a urinary carboxypeptidase Y-like kininase - Majima_1994_Jpn.J.Pharmacol_65_79 |
| Author(s) : Majima M , Kuribayashi Y , Ikeda Y , Adachi K , Kato H , Katori M , Aoyagi T |
| Ref : Japanese Journal of Pharmacology , 65 :79 , 1994 |
|
Abstract :
Ebelactone B (EB) (10(-7)-10(-5) M) inhibited dose-dependently carboxypeptidase (CP) Y-like exopeptidase, one of the major kininases separated from rat urine, whereas it inhibited neither CPA, CPB or neutral endopeptidase (NEP). Degradation of bradykinin (BK) to BK-(1-8) in rat urine was completely inhibited by EB (10(-5) M) with the increased generation of BK-(1-7). Intraduodenal administration of EB (3 mg/kg) to anesthetized rats caused marked diuresis (by 110%) and natriuresis (130%), in parallel with the increase in urinary kinin levels (110%). Intravenous infusion of a BK antagonist, Hoe140 (3 mg/kg/hr), strongly blocked both EB-induced diuresis and natriuresis. EB may be a novel type of diuretic and natriuretic agent that acts by increasing urinary kinin levels. |
| PubMedSearch : Majima_1994_Jpn.J.Pharmacol_65_79 |
| PubMedID: 8089934 |
Majima M, Kuribayashi Y, Ikeda Y, Adachi K, Kato H, Katori M, Aoyagi T (1994)
Diuretic and natriuretic effect of ebelactone B in anesthetized rats by inhibition of a urinary carboxypeptidase Y-like kininase
Japanese Journal of Pharmacology
65 :79
Majima M, Kuribayashi Y, Ikeda Y, Adachi K, Kato H, Katori M, Aoyagi T (1994)
Japanese Journal of Pharmacology
65 :79