Makuch_2001_Neurosci_104_81

Reference

Title : Arrival of afferents and the differentiation of target neurons: studies of developing cholinergic projections to the dentate gyrus - Makuch_2001_Neurosci_104_81
Author(s) : Makuch R , Baratta J , Karaelias LD , Lauterborn JC , Gall CM , Yu J , Robertson RT
Ref : Neuroscience , 104 :81 , 2001
Abstract :

This study examined the relationship between the development of cholinergic axons originating from the septum and a group of their target cells, the granule cells of the dentate gyrus of the rat. Acetylcholinesterase histochemistry was used to identify septal cholinergic afferents to the dentate gyrus; parallel studies used anterograde movement of a carbocyanine dye to label the septal projections. Septal cholinergic axons are present in the molecular layer of the internal blade of the dentate gyrus shortly after birth, but these axons do not reach the external blade until several days later. Results demonstrate that acetylcholinesterase positive septal axons grow into the external blade of the dentate gyrus only after the recently generated granule cells have coalesced to form a clearly defined layer. Results from studies using in situ hybridization techniques demonstrate that dentate gyrus granule cells express messenger RNAs for brain derived neurotrophic factor and for neurotrophic factor 3 shortly after formation of the granule cell layer. Ingrowth of septal cholinergic axons follows two days after the formation of the external blade of the dentate gyrus and the expression of neurotrophin messenger RNAs by the dentate granule cells. These data support the hypothesis that target cell development is a prerequisite for attracting the ingrowth of septal afferent axons.

PubMedSearch : Makuch_2001_Neurosci_104_81
PubMedID: 11311533

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Citations formats

Makuch R, Baratta J, Karaelias LD, Lauterborn JC, Gall CM, Yu J, Robertson RT (2001)
Arrival of afferents and the differentiation of target neurons: studies of developing cholinergic projections to the dentate gyrus
Neuroscience 104 :81

Makuch R, Baratta J, Karaelias LD, Lauterborn JC, Gall CM, Yu J, Robertson RT (2001)
Neuroscience 104 :81