Malicevic_1994_Vojnosanit.Pregl_51_192

The effect of thymopentin (TP-5; 1 x 10(-5) and 1 x 10(-4) M), the active center of the thymic hormone thymopoietin was examined upon spontaneous and induced neuromuscular synaptic activity (N-MS) in the isolated diaphragm of Wistar-strain rat. Standard electrophysiological method of intracellular registration was used. Analysis of original experimental microphysiologic results revealed clear depressant neuromodulative effect of TP-5 upon skeletal N-MS in vitro. Effect of TP-5 is expressed in decreased amount of the released median quantal value of neurotransmitter acetylcholine at orthodromic stimulation of the alpha-motor nerve. TP-5 also reduces chemiosensitivity of postsynaptic nicotinic acetylcholine receptors.