Malik_1987_Toxicol.Lett_36_289

Oral administration of fenitrothion (435 mg/kg) produced a pronounced fall in rectal temperature and erythrocyte AChE activity in buffalo calves. Treatment with DAM alone or in conjunction with atropine at the time of severe toxicity (within 1 h) significantly (P less than 0.01) reversed fenitrothion-induced hypothermia and AChE inhibition. The temperature decrease and AChE inhibition were not significantly (P greater than 0.05) altered by either 2-PAM or atropine. It is concluded that DAM may be more effective than either 2-PAM or atropine in reversing hypothermic effect of OP insecticides.