Maramai_2020_Biomed.Res.Int_2020_5120230

Reference

Title : Multitarget Therapeutic Strategies for Alzheimer's Disease: Review on Emerging Target Combinations - Maramai_2020_Biomed.Res.Int_2020_5120230
Author(s) : Maramai S , Benchekroun M , Gabr MT , Yahiaoui S
Ref : Biomed Res Int , 2020 :5120230 , 2020
Abstract :

Neurodegenerative diseases represent nowadays one of the major health problems. Despite the efforts made to unveil the mechanism leading to neurodegeneration, it is still not entirely clear what triggers this phenomenon and what allows its progression. Nevertheless, it is accepted that neurodegeneration is a consequence of several detrimental processes, such as protein aggregation, oxidative stress, and neuroinflammation, finally resulting in the loss of neuronal functions. Starting from these evidences, there has been a wide search for novel agents able to address more than a single event at the same time, the so-called multitarget-directed ligands (MTDLs). These compounds originated from the combination of different pharmacophoric elements which endowed them with the ability to interfere with different enzymatic and/or receptor systems, or to exert neuroprotective effects by modulating proteins and metal homeostasis. MTDLs have been the focus of the latest strategies to discover a new treatment for Alzheimer's disease (AD), which is considered the most common form of dementia characterized by neurodegeneration and cognitive dysfunctions. This review is aimed at collecting the latest and most interesting target combinations for the treatment of AD, with a detailed discussion on new agents with favorable in vitro properties and on optimized structures that have already been assessed in vivo in animal models of dementia.

PubMedSearch : Maramai_2020_Biomed.Res.Int_2020_5120230
PubMedID: 32714977

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Citations formats

Maramai S, Benchekroun M, Gabr MT, Yahiaoui S (2020)
Multitarget Therapeutic Strategies for Alzheimer's Disease: Review on Emerging Target Combinations
Biomed Res Int 2020 :5120230

Maramai S, Benchekroun M, Gabr MT, Yahiaoui S (2020)
Biomed Res Int 2020 :5120230