| Title : Photohuperzine A-A new photoisomer of huperzine A: structure elucidation, formation kinetics and activity assessment - Marques_2010_J.Pharm.Biomed.Anal_52_190 |
| Author(s) : Marques LA , Giera M , de Kanter FJ , Niessen WM , Lingeman H , Irth H |
| Ref : J Pharm Biomed Anal , 52 :190 , 2010 |
|
Abstract :
A new photoisomer of the promising "anti-Alzheimer" drug candidate (+/-) huperzine A is described. The new substance was formed via a photoisomerization reaction and was found to be 1-amino-13-ethylidene-11-methyl-6-aza-tetracyclo-[7.3.1.0(2.7).0(4.7)]-trideca-2,10-diene-5-one using NMR analysis. The kinetics of its formation was studied and proven to be of first-order. The described photoisomer showed a significant loss in activity, being more than 100 times less active than (-) huperzine A itself. The new substance was named photohuperzine A, referring to its photopyridone substructure. |
| PubMedSearch : Marques_2010_J.Pharm.Biomed.Anal_52_190 |
| PubMedID: 20133099 |
Marques LA, Giera M, de Kanter FJ, Niessen WM, Lingeman H, Irth H (2010)
Photohuperzine A-A new photoisomer of huperzine A: structure elucidation, formation kinetics and activity assessment
J Pharm Biomed Anal
52 :190
Marques LA, Giera M, de Kanter FJ, Niessen WM, Lingeman H, Irth H (2010)
J Pharm Biomed Anal
52 :190