Maryamabadi_2017_Bioorg.Med.Chem_25_2057

Reference

Title : Green synthesis of novel spiro-indenoquinoxaline derivatives and their cholinesterases inhibition activity - Maryamabadi_2017_Bioorg.Med.Chem_25_2057
Author(s) : Maryamabadi A , Hasaninejad A , Nowrouzi N , Mohebbi G
Ref : Bioorganic & Medicinal Chemistry , 25 :2057 , 2017
Abstract :

A convenient synthesis of substituted spiroindenoquinoxalines at mild and green conditions was developed. Multicomponent reaction of substituted phenylene diamines, ninhydrin, malononitrile and N,N'-substituted-2-nitroethene-1,1-diamines produced the target compounds. Twelve new spiroindenoquinoxalines were obtained, and their ability in inhibition of acetyl and butyrylcholinesterases were investigated both in vitro and in silico. All compounds showed moderate level activity against both acetyl and butyrylcholinesterases.

PubMedSearch : Maryamabadi_2017_Bioorg.Med.Chem_25_2057
PubMedID: 28279561

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Citations formats

Maryamabadi A, Hasaninejad A, Nowrouzi N, Mohebbi G (2017)
Green synthesis of novel spiro-indenoquinoxaline derivatives and their cholinesterases inhibition activity
Bioorganic & Medicinal Chemistry 25 :2057

Maryamabadi A, Hasaninejad A, Nowrouzi N, Mohebbi G (2017)
Bioorganic & Medicinal Chemistry 25 :2057