Marzel_2014_J.Clin.Microbiol_52_2078

Reference

Title : Integrative analysis of Salmonellosis in Israel reveals association of Salmonella enterica Serovar 9,12:l,v:- with extraintestinal infections, dissemination of endemic S. enterica Serovar Typhimurium DT104 biotypes, and severe underreporting of outbreaks - Marzel_2014_J.Clin.Microbiol_52_2078
Author(s) : Marzel A , Desai PT , Nissan I , Schorr YI , Suez J , Valinsky L , Reisfeld A , Agmon V , Guard J , McClelland M , Rahav G , Gal-Mor O
Ref : J Clin Microbiol , 52 :2078 , 2014
Abstract :

Salmonella enterica is the leading etiologic agent of bacterial food-borne outbreaks worldwide. This ubiquitous species contains more than 2,600 serovars that may differ in their host specificity, clinical manifestations, and epidemiology. To characterize salmonellosis epidemiology in Israel and to study the association of nontyphoidal Salmonella (NTS) serovars with invasive infections, 48,345 Salmonella cases reported and serotyped at the National Salmonella Reference Center between 1995 and 2012 were analyzed. A quasi-Poisson regression was used to identify irregular clusters of illness, and pulsed-field gel electrophoresis in conjunction with whole-genome sequencing was applied to molecularly characterize strains of interest. Three hundred twenty-nine human salmonellosis clusters were identified, representing an annual average of 23 (95% confidence interval [CI], 20 to 26) potential outbreaks. We show that the previously unsequenced S. enterica serovar 9,12:l,v:- belongs to the B clade of Salmonella enterica subspecies enterica, and we show its frequent association with extraintestinal infections, compared to other NTS serovars. Furthermore, we identified the dissemination of two prevalent Salmonella enterica serovar Typhimurium DT104 clones in Israel, which are genetically distinct from other global DT104 isolates. Accumulatively, these findings indicate a severe underreporting of Salmonella outbreaks in Israel and provide insights into the epidemiology and genomics of prevalent serovars, responsible for recurring illness.

PubMedSearch : Marzel_2014_J.Clin.Microbiol_52_2078
PubMedID: 24719441

Related information

Citations formats

Marzel A, Desai PT, Nissan I, Schorr YI, Suez J, Valinsky L, Reisfeld A, Agmon V, Guard J, McClelland M, Rahav G, Gal-Mor O (2014)
Integrative analysis of Salmonellosis in Israel reveals association of Salmonella enterica Serovar 9,12:l,v:- with extraintestinal infections, dissemination of endemic S. enterica Serovar Typhimurium DT104 biotypes, and severe underreporting of outbreaks
J Clin Microbiol 52 :2078

Marzel A, Desai PT, Nissan I, Schorr YI, Suez J, Valinsky L, Reisfeld A, Agmon V, Guard J, McClelland M, Rahav G, Gal-Mor O (2014)
J Clin Microbiol 52 :2078