Mashimo_2021_Int.J.Mol.Sci_22_

Reference

Title : Regulation of Immune Functions by Non-Neuronal Acetylcholine (ACh) via Muscarinic and Nicotinic ACh Receptors - Mashimo_2021_Int.J.Mol.Sci_22_
Author(s) : Mashimo M , Moriwaki Y , Misawa H , Kawashima K , Fujii T
Ref : Int J Mol Sci , 22 : , 2021
Abstract :

Acetylcholine (ACh) is the classical neurotransmitter in the cholinergic nervous system. However, ACh is now known to regulate various immune cell functions. In fact, T cells, B cells, and macrophages all express components of the cholinergic system, including ACh, muscarinic, and nicotinic ACh receptors (mAChRs and nAChRs), choline acetyltransferase, acetylcholinesterase, and choline transporters. In this review, we will discuss the actions of ACh in the immune system. We will first briefly describe the mechanisms by which ACh is stored in and released from immune cells. We will then address Ca(2+) signaling pathways activated via mAChRs and nAChRs on T cells and B cells, highlighting the importance of ACh for the function of T cells, B cells, and macrophages, as well as its impact on innate and acquired (cellular and humoral) immunity. Lastly, we will discuss the effects of two peptide ligands, secreted lymphocyte antigen-6/urokinase-type plasminogen activator receptor-related peptide-1 (SLURP-1) and hippocampal cholinergic neurostimulating peptide (HCNP), on cholinergic activity in T cells. Overall, we stress the fact that ACh does not function only as a neurotransmitter; it impacts immunity by exerting diverse effects on immune cells via mAChRs and nAChRs.

PubMedSearch : Mashimo_2021_Int.J.Mol.Sci_22_
PubMedID: 34202925

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Citations formats

Mashimo M, Moriwaki Y, Misawa H, Kawashima K, Fujii T (2021)
Regulation of Immune Functions by Non-Neuronal Acetylcholine (ACh) via Muscarinic and Nicotinic ACh Receptors
Int J Mol Sci 22 :

Mashimo M, Moriwaki Y, Misawa H, Kawashima K, Fujii T (2021)
Int J Mol Sci 22 :