| Title : Cysteine string proteins: a potential link between synaptic vesicles and presynaptic Ca2+ channels - Mastrogiacomo_1994_Science_263_981 |
| Author(s) : Mastrogiacomo A , Parsons SM , Zampighi GA , Jenden DJ , Umbach JA , Gundersen CB |
| Ref : Science , 263 :981 , 1994 |
|
Abstract :
Presynaptic calcium channels are key regulators of neurotransmitter release. Oocyte expression studies suggest that cysteine string proteins are essential subunits or modulators of these channels. Subcellular fractionation revealed that cysteine string proteins copurify with synaptic vesicles. An average vesicle had eight protein monomers with both the amino and carboxyl termini detected on the cytoplasmic face. Thus, docked synaptic vesicles may regulate presynaptic calcium channels and neurotransmitter release. |
| PubMedSearch : Mastrogiacomo_1994_Science_263_981 |
| PubMedID: 7906056 |
Mastrogiacomo A, Parsons SM, Zampighi GA, Jenden DJ, Umbach JA, Gundersen CB (1994)
Cysteine string proteins: a potential link between synaptic vesicles and presynaptic Ca2+ channels
Science
263 :981
Mastrogiacomo A, Parsons SM, Zampighi GA, Jenden DJ, Umbach JA, Gundersen CB (1994)
Science
263 :981