| Title : Intact human lymphocyte membranes respond to muscarinic receptor stimulation by oxotremorine with marked changes in microviscosity and an increase in cyclic GMP - Masturzo_1985_FEBS.Lett_192_194 |
| Author(s) : Masturzo P , Salmona M , Nordstrom O , Consolo S , Ladinsky H |
| Ref : FEBS Letters , 192 :194 , 1985 |
|
Abstract :
The muscarinic agonist oxotremorine produced a linear dose-dependent increase in membrane fluidity of intact and viable human lymphocytes in vitro. This effect proved to be receptor-mediated because preincubation with 10(-5)M atropine shifted the dose-response curve one order of magnitude rightward. Pirenzepine preincubation did not affect membrane fluidity variation. A cGMP increase was also found after oxotremorine treatment. The results are discussed in terms of possible modulation of guanyl cyclase and adenyl cyclase through membrane fluidity variations. |
| PubMedSearch : Masturzo_1985_FEBS.Lett_192_194 |
| PubMedID: 2998866 |
Masturzo P, Salmona M, Nordstrom O, Consolo S, Ladinsky H (1985)
Intact human lymphocyte membranes respond to muscarinic receptor stimulation by oxotremorine with marked changes in microviscosity and an increase in cyclic GMP
FEBS Letters
192 :194
Masturzo P, Salmona M, Nordstrom O, Consolo S, Ladinsky H (1985)
FEBS Letters
192 :194