Mavroidi_2022_Brain.Sci_12_

Reference

Title : The Prophylactic and Multimodal Activity of Two Isatin Thiosemicarbazones against Alzheimer's Disease In Vitro - Mavroidi_2022_Brain.Sci_12_
Author(s) : Mavroidi B , Kaminari A , Matiadis D , Hadjipavlou-Litina D , Pelecanou M , Tzinia A , Sagnou M
Ref : Brain Sci , 12 : , 2022
Abstract :

Alzheimer's disease (AD) is a multifactorial disorder strongly involving the formation of amyloid-beta (Abeta) oligomers, which subsequently aggregate into the disease characteristic insoluble amyloid plaques, in addition to oxidative stress, inflammation and increased acetylcholinesterase activity. Moreover, Abeta oligomers interfere with the expression and activity of Glycogen synthase kinase-3 (GSK3) and Protein kinase B (PKB), also known as AKT. In the present study, the potential multimodal effect of two synthetic isatin thiosemicarbazones (ITSCs), which have been previously shown to prevent Abeta aggregation was evaluated. Both compounds resulted in fully reversing the Abeta-mediated toxicity in SK-NS-H cells treated with exogenous Abeta peptides at various pre-incubation time points and at 1 microM. Cell survival was not recovered when compounds were applied after Abeta cell treatment. The ITSCs were non-toxic against wild type and 5xFAD primary hippocampal cells. They reversed the inhibition of Akt and GSK-3beta phosphorylation in 5xFAD cells. Finally, they exhibited good antioxidant potential and moderate lipoxygenase and acetylcholinesterase inhibition activity. Overall, these results suggest that isatin thiosemicarbazone is a suitable scaffold for the development of multimodal anti-AD agents.

PubMedSearch : Mavroidi_2022_Brain.Sci_12_
PubMedID: 35741690

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Citations formats

Mavroidi B, Kaminari A, Matiadis D, Hadjipavlou-Litina D, Pelecanou M, Tzinia A, Sagnou M (2022)
The Prophylactic and Multimodal Activity of Two Isatin Thiosemicarbazones against Alzheimer's Disease In Vitro
Brain Sci 12 :

Mavroidi B, Kaminari A, Matiadis D, Hadjipavlou-Litina D, Pelecanou M, Tzinia A, Sagnou M (2022)
Brain Sci 12 :