Mayasankaravalli_2020_Saudi.J.Biol.Sci_27_3228

Reference

Title : Profiling the phyto-constituents of Punica granatum fruits peel extract and accessing its in-vitro antioxidant, anti-diabetic, anti-obesity, and angiotensin-converting enzyme inhibitory properties - Mayasankaravalli_2020_Saudi.J.Biol.Sci_27_3228
Author(s) : Mayasankaravalli C , Deepika K , Esther Lydia D , Agada R , Thagriki D , Govindasamy C , Chinnadurai V , Othman Gatar OM , Khusro A , Kim YO , Kim HJ
Ref : Saudi J Biol Sci , 27 :3228 , 2020
Abstract :

This context was investigated to assess the in vitro antioxidant, anti-diabetic, anti-obesity, and angiotensin-converting enzyme (ACE) inhibition traits of Punica granatum fruits peel extract. Initially, among various extracts tested, aqueous and ethanolic peel extracts depicted the presence of diverse phytoconstituents. In vitro antioxidative properties of peel extracts were determined using standard methodologies. Results showed that aqueous and ethanolic extracts had IC(50) values of 471.7 and 509.16 g/mL, respectively in terms of 1,1,diphenyl 2,2,picrylhydrazyl scavenging. Likewise, IC(50) values of aqueous and ethanol extract were obtained as 488.76 and 478.47 g/mL towards the degradation of hydrogen peroxide. The ethanolic extract exhibited the highest inhibition of alpha-glucosidase by showing activity of 53.34 +/- 2.0 to 15.18 +/- 1.4 U/L in a dose dependent manner (100-1000 microg/mL). Ethanolic extract was reported as the most active inhibitor of lipase with an IC(50) value of 603.50 microg/mL. Ethanolic extract showed increased inhibition of ACE in a concentration dependent manner (100-1000 microg/mL) with IC(50) value of 519.45 microg/mL. Fourier transform-infrared spectrum revealed the availability of various functional groups in the ethanolic extract of peel. Gas chromatography-mass spectrometry chromatogram of peel extract illustrated 23 diversified chemical constituents including 1,2,3,4-butanetetrol, Dimethyl sulfone, 9-octadecenamide, and Pentadecanoic acid as predominant compounds. In summary, P. granatum fruits peel extract revealed promising antioxidant, anti-diabetic, anti-obesity, and anti-hypertensive properties.

PubMedSearch : Mayasankaravalli_2020_Saudi.J.Biol.Sci_27_3228
PubMedID: 33304128

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Citations formats

Mayasankaravalli C, Deepika K, Esther Lydia D, Agada R, Thagriki D, Govindasamy C, Chinnadurai V, Othman Gatar OM, Khusro A, Kim YO, Kim HJ (2020)
Profiling the phyto-constituents of Punica granatum fruits peel extract and accessing its in-vitro antioxidant, anti-diabetic, anti-obesity, and angiotensin-converting enzyme inhibitory properties
Saudi J Biol Sci 27 :3228

Mayasankaravalli C, Deepika K, Esther Lydia D, Agada R, Thagriki D, Govindasamy C, Chinnadurai V, Othman Gatar OM, Khusro A, Kim YO, Kim HJ (2020)
Saudi J Biol Sci 27 :3228