Mayer_2012_Anal.Chem_84_10478

Reference

Title : 31P-edited diffusion-ordered 1H NMR spectroscopy for the spectral isolation and identification of organophosphorus compounds related to chemical weapons agents and their degradation products - Mayer_2012_Anal.Chem_84_10478
Author(s) : Mayer BP , Valdez CA , Hok S , Chinn SC , Hart BR
Ref : Analytical Chemistry , 84 :10478 , 2012
Abstract :

Organophosphorus compounds represent a large class of molecules that include pesticides, flame-retardants, biologically relevant molecules, and chemical weapons agents (CWAs). The detection and identification of organophosphorus molecules, particularly in the cases of pesticides and CWAs, are paramount to the verification of international treaties by various organizations. To that end, novel analytical methodologies that can provide additional support to traditional analyses are important for unambiguous identification of these compounds. We have developed an NMR method that selectively edits for organophosphorus compounds via (31)P-(1)H heteronuclear single quantum correlation (HSQC) and provides an additional chromatographic-like separation based on self-diffusivities of the individual species via (1)H diffusion-ordered spectroscopy (DOSY): (1)H-(31)P HSQC-DOSY. The technique is first validated using the CWA VX (O-ethyl S-[2-(diisopropylamino)ethyl] methylphosphonothioate) by traditional two-dimensional DOSY spectra. We then extend this technique to a complex mixture of VX degradation products and identify all the main phosphorus-containing byproducts generated after exposure to a zinc-cyclen organometallic homogeneous catalyst.

PubMedSearch : Mayer_2012_Anal.Chem_84_10478
PubMedID: 23126561

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Citations formats

Mayer BP, Valdez CA, Hok S, Chinn SC, Hart BR (2012)
31P-edited diffusion-ordered 1H NMR spectroscopy for the spectral isolation and identification of organophosphorus compounds related to chemical weapons agents and their degradation products
Analytical Chemistry 84 :10478

Mayer BP, Valdez CA, Hok S, Chinn SC, Hart BR (2012)
Analytical Chemistry 84 :10478