Mazzon_2012_Blood_119_5502

Reference

Title : Agrin is required for survival and function of monocytic cells - Mazzon_2012_Blood_119_5502
Author(s) : Mazzon C , Anselmo A , Soldani C , Cibella J , Ploia C , Moalli F , Burden SJ , Dustin ML , Sarukhan A , Viola A
Ref : Blood , 119 :5502 , 2012
Abstract :

Agrin, an extracellular matrix protein belonging to the heterogeneous family of heparan sulfate proteoglycans (HSPGs), is expressed by cells of the hematopoietic system but its role in leukocyte biology is not yet clear. Here we demonstrate that agrin has a crucial, nonredundant role in myeloid cell development and functions. We have identified lineage-specific alterations that affect maturation, survival and properties of agrin-deficient monocytic cells, and occur at stages later than stem cell precursors. Our data indicate that the cell-autonomous signals delivered by agrin are sensed by macrophages through the alpha-DC (DG) receptor and lead to the activation of signaling pathways resulting in rearrangements of the actin cytoskeleton during the phagocytic synapse formation and phosphorylation of extracellular signal-regulated kinases (Erk 1/2). Altogether, these data identify agrin as a novel player of innate immunity.

PubMedSearch : Mazzon_2012_Blood_119_5502
PubMedID: 22517892

Related information

Citations formats

Mazzon C, Anselmo A, Soldani C, Cibella J, Ploia C, Moalli F, Burden SJ, Dustin ML, Sarukhan A, Viola A (2012)
Agrin is required for survival and function of monocytic cells
Blood 119 :5502

Mazzon C, Anselmo A, Soldani C, Cibella J, Ploia C, Moalli F, Burden SJ, Dustin ML, Sarukhan A, Viola A (2012)
Blood 119 :5502