McKeith_2004_Parkinsonism.Relat.Disord_10 Suppl 1_S15


Title : Dementia with Lewy bodies and Parkinson's disease - McKeith_2004_Parkinsonism.Relat.Disord_10 Suppl 1_S15
Author(s) : McKeith IG , Mosimann UP
Ref : Parkinsonism Relat Disord , 10 Suppl 1 :S15 , 2004
Abstract :

Lewy bodies (LB) in the central nervous system are associated with several different clinical syndromes including Parkinson's disease (PD) and dementia with Lewy bodies (DLB). Long term follow up of PD patients finds up to 78% eventually develop dementia, most of these patients exhibiting fluctuating cognition and visual hallucinations similar to DLB and with extensive cortical LB at autopsy. alpha-Synuclein positive, neuritic pathology, in the putamen of DLB and Parkinson's disease dementia (PDD), may contribute to postural-instability gait difficulty, parkinsonism, diminished levodopa responsiveness and increased neuroleptic sensitivity. Cognitive and neuropsychiatric symptoms improve with cholinesterase inhibitor treatment in both patient groups. DLB and PDD should be seen as different points on a spectrum of LB disease. Distinguishing them as separate disorders may be useful in clinical practice, but may be of limited value in terms of investigating and treating the underlying neurobiology.

PubMedSearch : McKeith_2004_Parkinsonism.Relat.Disord_10 Suppl 1_S15
PubMedID: 15109582

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Citations formats

McKeith IG, Mosimann UP (2004)
Dementia with Lewy bodies and Parkinson's disease
Parkinsonism Relat Disord 10 Suppl 1 :S15

McKeith IG, Mosimann UP (2004)
Parkinsonism Relat Disord 10 Suppl 1 :S15