Title : Age-dependent variation in response to tubocurarine in the isolated rat diaphragm - Meakin_1992_Br.J.Anaesth_68_161 |
Author(s) : Meakin G , Morton RH , Wareham AC |
Ref : British Journal of Anaesthesia , 68 :161 , 1992 |
Abstract :
The EC50 of tubocurarine was determined in phrenic nerve-hemidiaphragm preparations obtained from 35 Sprague-Dawley rats aged 0-46 days. We measured also the ratio of the fourth to the first twitch in the train-of-four (T4:T1) when the first twitch of the train was depressed to 50% of control. The preparation was not unduly sensitive to tubocurarine at 0 days and there was little evidence of T4:T1 fade. However, by age 11 days the preparation exhibited fade and a three-fold sensitivity to tubocurarine similar to that in the human neonate. We conclude that the phrenic nerve-hemidiaphragm preparation from 11-day-old rats should be a suitable model in which to investigate the biochemical and electrophysiological basis of the sensitivity seen in humans. |
PubMedSearch : Meakin_1992_Br.J.Anaesth_68_161 |
PubMedID: 1540457 |
Meakin G, Morton RH, Wareham AC (1992)
Age-dependent variation in response to tubocurarine in the isolated rat diaphragm
British Journal of Anaesthesia
68 :161
Meakin G, Morton RH, Wareham AC (1992)
British Journal of Anaesthesia
68 :161