| Title : Two birds with one stone: The detection of nerve agents and AChE activity with an ICT-ESIPT-based fluorescence sensor - Meng_2020_J.Hazard.Mater_410_124811 |
| Author(s) : Meng W , Pei Z , Wang Y , Sun M , Xu Q , Cen J , Guo K , Xiao K , Li Z |
| Ref : J Hazard Mater , 410 :124811 , 2020 |
| Abstract : Nerve agents are among the world's deadliest poisons, and the target enzyme is acetylcholinesterase (AChE). To better diagnosis nerve agent poisonings, a reliable diagnostic method for both nerve agents and AChE is desirable. Herein, we synthesized a series of fluorescent sensors for both real nerve agents and acetylcholinesterase activity detection. Among these sensors, HBQ-AE exhibited a fast response rate (within 10 s for nerve agent and 8 min for AChE), good sensitivity (the limit of detection is 6 nM and 0.2 U/mL) and a high off/on contrast. To the best of our knowledge, HBQ-AE is the first fluorescence sensor for nerve agents and AChE activity detection. The fluorescent change of HBQ-AE from nonfluorescence to blue fluorescence (nerve agent) or orange fluorescence (AChE) by excitation at 365 nm can be easily observed with the naked eye. HBQ-AE was successfully applied to image nerve agents and AChE activity in living cells. Moreover, HBQ-AE is the vital member to construct a test paper that can be employed to detect and diagnose chemical warfare agents. |
| ESTHER : Meng_2020_J.Hazard.Mater_410_124811 |
| PubMedSearch : Meng_2020_J.Hazard.Mater_410_124811 |
| PubMedID: 33450470 |
Meng W, Pei Z, Wang Y, Sun M, Xu Q, Cen J, Guo K, Xiao K, Li Z (2020)
Two birds with one stone: The detection of nerve agents and AChE activity with an ICT-ESIPT-based fluorescence sensor
J Hazard Mater
410 :124811
Meng W, Pei Z, Wang Y, Sun M, Xu Q, Cen J, Guo K, Xiao K, Li Z (2020)
J Hazard Mater
410 :124811