Mertens_1975_Psychopharmacologia_41_47

The need for study of the effects on performance of non-lethal organophosphate insecticide exposure is founded on many reports of behavioral difficulties in aerial applicators following exposure. In this study, a different pair of gerbils served in each of the following schedules of reinforcement: FR 25, FR 75, DRL 12-sec, DRL 20-sec, and VI 1-min. Baseline performance in these tasks tended to be comparable to that of more common laboratory species, but was more variable in the case of the VI 1-min task. Mevinphos doses of 0.20 mg/kg and above produced observable somatic signs of poisoning and also produced dose-related decrements in performance in FR and VI tasks. Performance in the DRL schedule was affected only at a dose of 0.30 mg/kg. No performance deficits or overt somatic signs of poisoning were present at mevinphos doses of 0.10 mg/kg or lower. These results do not agree with those of an earlier study which decrements in VI performance of pigeons and squirrel monkeys appeared at low mevinphos doses which did not produce overt somatic signs of poisoning. The possibility of variations in mevinphos effect as a function of species and task was discussed.