| Title : Evidence for a direct relationship between phosphoinositide metabolism and airway smooth muscle contraction induced by muscarinic agonists - Meurs_1988_Eur.J.Pharmacol_156_271 |
| Author(s) : Meurs H , Roffel AF , Postema JB , Timmermans A , Elzinga CR , Kauffman HF , Zaagsma J |
| Ref : European Journal of Pharmacology , 156 :271 , 1988 |
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Abstract :
The relationship between bovine tracheal muscle contraction and phosphoinositide metabolism was studied with the muscarinic agonists, methacholine, oxotremorine, and McN-A-343. Analysis of the dose-response curves for contraction and inositol phosphates accumulation with these agonists demonstrated a direct relationship between the two parameters, with a considerable reserve of inositol phosphate production for the full contractile agonists, methacholine and oxotremorine, and no reserve for the partial agonist, McN-A-343. |
| PubMedSearch : Meurs_1988_Eur.J.Pharmacol_156_271 |
| PubMedID: 2467823 |
Meurs H, Roffel AF, Postema JB, Timmermans A, Elzinga CR, Kauffman HF, Zaagsma J (1988)
Evidence for a direct relationship between phosphoinositide metabolism and airway smooth muscle contraction induced by muscarinic agonists
European Journal of Pharmacology
156 :271
Meurs H, Roffel AF, Postema JB, Timmermans A, Elzinga CR, Kauffman HF, Zaagsma J (1988)
European Journal of Pharmacology
156 :271