Title : Protective effect of donepezil on retinal ganglion cells in vitro and in vivo - Miki_2006_Curr.Eye.Res_31_69 |
Author(s) : Miki A , Otori Y , Morimoto T , Okada M , Tano Y |
Ref : Current Eye Research , 31 :69 , 2006 |
Abstract :
The neuroprotective effect of donepezil, an acetylcholinesterase inhibitor on retinal ganglion cells (RGCs), was examined. The survival of purified RGCs after exposure to glutamate with or without donepezil (10(- 7) M to 10(- 5) M) was measured after 3 days in culture. In vivo, the neuroprotective effect of donepezil was examined by quantifying the number of viable RGCs 7 days after axotomy in adult rats. In vitro, donepezil dose-dependently reduced RGC death caused by glutamate toxicity. Oral administration of donepezil (10 mg kg(-1) day(-1)) significantly reduced RGC death after axotomy. In conclusion, donepezil exerts a protective effect on RGCs both in vitro and in vivo. |
PubMedSearch : Miki_2006_Curr.Eye.Res_31_69 |
PubMedID: 16421021 |
Miki A, Otori Y, Morimoto T, Okada M, Tano Y (2006)
Protective effect of donepezil on retinal ganglion cells in vitro and in vivo
Current Eye Research
31 :69
Miki A, Otori Y, Morimoto T, Okada M, Tano Y (2006)
Current Eye Research
31 :69