Mindel_1982_Arch.Ophthalmol_100_147

Reference

Title : The effect of echothiophate on the biphasic response of rabbit ocular pressure to dipivefrin - Mindel_1982_Arch.Ophthalmol_100_147
Author(s) : Mindel JS , Koenigsberg AM , Kharlamb AB , Goldfarb J , Orellana J
Ref : Archives of Ophthalmologymol , 100 :147 , 1982
Abstract : A time-course study was performed on the intraocular pressure response of pigmented rabbit eyes. Dipivefrin administration produced in initial hypertensive phase lasting less than two hours followed by a prolonged hypotensive phase. Echothiophate iodide therapy produced a more pronounced and prolonged hypertensive response; there was no hypotensive phase. Administration of echothiophate plus dipivefrin resulted in a hypertensive phase similar to that from echothiophate alone; as previously reported, this combination was not followed by a hypotensive phase. The alpha-blocker phentolamine mesylate prevented the echothiophate-induced hypertension. When dipivefrin was administered with echothiophate plus phentolamine, there was an immediate hypotensive effect. It was concluded that the hypertensive effect of echothiophate in pigmented rabbit eyes may mask the hypotensive action of dipivefrin. This, rather than an echothiophate-induced inhibition of esterases, may explain why combination therapy with these drugs seemed ineffective.
ESTHER : Mindel_1982_Arch.Ophthalmol_100_147
PubMedSearch : Mindel_1982_Arch.Ophthalmol_100_147
PubMedID: 6173032

Related information

Substrate Dipivefrin

Citations formats

Mindel JS, Koenigsberg AM, Kharlamb AB, Goldfarb J, Orellana J (1982)
The effect of echothiophate on the biphasic response of rabbit ocular pressure to dipivefrin
Archives of Ophthalmologymol 100 :147

Mindel JS, Koenigsberg AM, Kharlamb AB, Goldfarb J, Orellana J (1982)
Archives of Ophthalmologymol 100 :147