| Title : 1H-Pyrazolo[3,4-b]pyridine inhibitors of cyclin-dependent kinases - Misra_2003_Bioorg.Med.Chem.Lett_13_1133 |
| Author(s) : Misra RN , Rawlins DB , Xiao HY , Shan W , Bursuker I , Kellar KA , Mulheron JG , Sack JS , Tokarski JS , Kimball SD , Webster KR |
| Ref : Bioorganic & Medicinal Chemistry Lett , 13 :1133 , 2003 |
|
Abstract :
1H-Pyrazolo[3,4-b]pyridine 3 (SQ-67563) has been shown to be a potent, selective inhibitor of CDK1/CDK2 in vitro. In cells 3 acts as a cytotoxic agent with the ability to block cell cycle progression and/or induce apoptosis. The solid state structure of 3 bound to CDK2 shows 3 resides coincident with the ATP purine binding site and forms important H-bonding interactions with Leu83 on the protein backbone. |
| PubMedSearch : Misra_2003_Bioorg.Med.Chem.Lett_13_1133 |
| PubMedID: 12643928 |
Misra RN, Rawlins DB, Xiao HY, Shan W, Bursuker I, Kellar KA, Mulheron JG, Sack JS, Tokarski JS, Kimball SD, Webster KR (2003)
1H-Pyrazolo[3,4-b]pyridine inhibitors of cyclin-dependent kinases
Bioorganic & Medicinal Chemistry Lett
13 :1133
Misra RN, Rawlins DB, Xiao HY, Shan W, Bursuker I, Kellar KA, Mulheron JG, Sack JS, Tokarski JS, Kimball SD, Webster KR (2003)
Bioorganic & Medicinal Chemistry Lett
13 :1133