| Title : Dynamic subcellular localization of aquaporin-7 in white adipocytes - Miyauchi_2015_FEBS.Lett_589_608 |
| Author(s) : Miyauchi T , Yamamoto H , Abe Y , Yoshida GJ , Rojek A , Sohara E , Uchida S , Nielsen S , Yasui M |
| Ref : FEBS Letters , 589 :608 , 2015 |
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Abstract :
Aquaporin-7 (AQP7) is expressed in adipose tissue, permeated by water and glycerol, and is involved in lipid metabolism. AQP7-null mice develop obesity, insulin resistance, and adipocyte hypertrophy. Here, we show that AQP7 is expressed in adipocyte plasma membranes, and is re-localized to intracellular membranes in response to catecholamine in mouse white adipose tissue. We found that internalization of AQP7 was induced by PKA activation and comparative gene identification 58 (CGI-58). This relocation was confirmed by functional studies in 3T3-L1 adipocytes. Collectively, these results suggest that AQP7 makes several contributions to adipocyte metabolism, in both cortical and intracellular membranes. |
| PubMedSearch : Miyauchi_2015_FEBS.Lett_589_608 |
| PubMedID: 25643985 |
Miyauchi T, Yamamoto H, Abe Y, Yoshida GJ, Rojek A, Sohara E, Uchida S, Nielsen S, Yasui M (2015)
Dynamic subcellular localization of aquaporin-7 in white adipocytes
FEBS Letters
589 :608
Miyauchi T, Yamamoto H, Abe Y, Yoshida GJ, Rojek A, Sohara E, Uchida S, Nielsen S, Yasui M (2015)
FEBS Letters
589 :608