| Title : Design, synthesis and biological evaluation of new 1,3-thiazole derivatives as potential anti-inflammatory agents - Modric_2021_J.Mol.Struct_1239_130526 |
| Author(s) : Modric M , Bozicevic M , Faraho I , Bosnar M , Skoric I |
| Ref : J Mol Struct , 1239 :130526 , 2021 |
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Abstract :
Thiazoles are widely recognized as nuclei of great value for obtaining molecules with various biological activities, including analgesic, anti-inflammatory, anti-HIV, antidiabetic, antitumor and antimicrobial. A library of 26 thiazole derivatives as fragments were designed, synthesized and evaluated for their anti-inflammatory activities. Some screened compounds showed promising results and were found to be potent in the series by inhibiting LPS-induced TNFa and IL-8 release with IC50 values in M range without cytotoxic activity. |
| PubMedSearch : Modric_2021_J.Mol.Struct_1239_130526 |
| PubMedID: |
Modric M, Bozicevic M, Faraho I, Bosnar M, Skoric I (2021)
Design, synthesis and biological evaluation of new 1,3-thiazole derivatives as potential anti-inflammatory agents
J Mol Struct
1239 :130526
Modric M, Bozicevic M, Faraho I, Bosnar M, Skoric I (2021)
J Mol Struct
1239 :130526