| Title : Firefly luciferin methyl ester illuminates the activity of multiple serine hydrolases - Mohammad_2023_Chem.Commun.(Camb)__ |
| Author(s) : Mohammad I , Liebmann KL , Miller SC |
| Ref : Chem Commun (Camb) , : , 2023 |
|
Abstract :
Firefly luciferin methyl ester is hydrolyzed by monoacylglycerol lipase MAGL, amidase FAAH, poorly-characterized hydrolase ABHD11, and hydrolases known for S-depalmitoylation (LYPLA1/2), not just esterase CES1. This enables activity-based bioluminescent assays for serine hydrolases and suggests that the 'esterase activity' responsible for hydrolyzing ester prodrugs is more diverse than previously supposed. |
| PubMedSearch : Mohammad_2023_Chem.Commun.(Camb)__ |
| PubMedID: 37337906 |
| Substrate | D-luciferin-methyl-ester |
Mohammad I, Liebmann KL, Miller SC (2023)
Firefly luciferin methyl ester illuminates the activity of multiple serine hydrolases
Chem Commun (Camb)
:
Mohammad I, Liebmann KL, Miller SC (2023)
Chem Commun (Camb)
: