| Title : Design, Synthesis, Biological Evaluation, and Docking Study of Acetylcholinesterase Inhibitors: New Acridone-1,2,4-oxadiazole-1,2,3-triazole Hybrids - Mohammadi-Khanaposhtani_2015_Chem.Biol.Drug.Des_86_1425 |
| Author(s) : Mohammadi-Khanaposhtani M , Mahdavi M , Saeedi M , Sabourian R , Safavi M , Khanavi M , Foroumadi A , Shafiee A , Akbarzadeh T |
| Ref : Chemical Biology Drug Des , 86 :1425 , 2015 |
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Abstract :
In this study, novel acridone-1,2,4-oxadiazole-1,2,3-triazole hybrids were designed, synthesized, and evaluated for their acetylcholinesterase and butyrylcholinesterase inhibitory activity. Among various synthesized compounds, 10-((1-((3-(4-methoxyphenyl)-1,2,4-oxadiazol-5-yl)methyl)-1H-1,2,3-triazol-4-yl)m ethyl)acridin-9(10H)-one 10b showed the most potent anti-acetylcholinesterase activity (IC50 = 11.55 mum) being as potent as rivastigmine. Also docking outcomes were in good agreement with in vitro results confirming the dual binding inhibitory activity of compound 10b. |
| PubMedSearch : Mohammadi-Khanaposhtani_2015_Chem.Biol.Drug.Des_86_1425 |
| PubMedID: 26077890 |
Mohammadi-Khanaposhtani M, Mahdavi M, Saeedi M, Sabourian R, Safavi M, Khanavi M, Foroumadi A, Shafiee A, Akbarzadeh T (2015)
Design, Synthesis, Biological Evaluation, and Docking Study of Acetylcholinesterase Inhibitors: New Acridone-1,2,4-oxadiazole-1,2,3-triazole Hybrids
Chemical Biology Drug Des
86 :1425
Mohammadi-Khanaposhtani M, Mahdavi M, Saeedi M, Sabourian R, Safavi M, Khanavi M, Foroumadi A, Shafiee A, Akbarzadeh T (2015)
Chemical Biology Drug Des
86 :1425