Monhart_1994_Artif.Organs_18_770

Reference

Title : Use of hemoperfusion in experimental intoxication with nerve agents - Monhart_1994_Artif.Organs_18_770
Author(s) : Monhart V , Fusek J , Brndiar M , Tlustakova M
Ref : Artif Organs , 18 :770 , 1994
Abstract :

The aim of this study was to evaluate the efficiency of hemoperfusion (HP) through coated resin adsorbent Synachrom E-5 in animal intoxications with organophosphate inhibitors of cholinesterases type of nerve agents. Five anesthetized dogs were intoxicated with 2 to 6 LD50 of VX substance and another 4 with 2 to 3 LD50 sarine. Both nerve agents were given i.m. after starting 5 h HP. The clinical and laboratory tests were monitored during each HP. HP therapy prevented the development of serious signs of intoxication provided that the administered quantity of both sarine and the VX substance was only 2 doses of LD50. Specific antidote therapy was necessary to prevent cardiorespiratory failure in animals intoxicated with a higher dose of poison. The results obtained show that HP through Synachrom E-5 in intoxication with nerve agents sarine and the VX type is only partially successful.

PubMedSearch : Monhart_1994_Artif.Organs_18_770
PubMedID: 7832660

Related information

Inhibitor Sarin    VX

Citations formats

Monhart V, Fusek J, Brndiar M, Tlustakova M (1994)
Use of hemoperfusion in experimental intoxication with nerve agents
Artif Organs 18 :770

Monhart V, Fusek J, Brndiar M, Tlustakova M (1994)
Artif Organs 18 :770